About Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes caused by prolonged high blood sugar levels damaging the peripheral nerves, primarily in the hands, feet, legs, and arms. Chronic hyperglycemia leads to oxidative stress, the formation of harmful advanced glycation end products (AGEs), and inflammation, all of which contribute to nerve damage. Additionally, impaired blood flow due to microvascular complications and abnormal lipid metabolism further exacerbate the condition. Genetic predisposition and lifestyle factors like smoking, obesity, and inactivity can increase the risk of DPN.
Symptoms include numbness, tingling, burning sensations, sharp pain, and muscle weakness, often beginning in the extremities. Prevention and management focus on maintaining tight blood sugar control, adopting a healthy lifestyle, and addressing risk factors. Medications such as antidepressants or anticonvulsants can help manage pain, while regular foot care can prevent complications. Early diagnosis and intervention are crucial to slowing progression and improving quality of life.